عنوان مقاله [English]
نویسندگان [English]چکیده [English]
Numerous neurotransmitters are responsible for in sensation and process of pain in the nervous system. But the
role of cholinergic system has not been properly studied. Thus in order to study the cholinergic antagonistic effects
in pain, the effect of atropine (10 mg/ kg/IP) on chronic pain, has been studied on male and female mice by
intraplantar injection of 2.5% formalin (Formalin test).
The results obtained indicated that male mice treated by atropine had a higher pain threshold in comparison to
the reference group. In the meantime, this test in the female reference group showed a significant increase in the
threshold of pain. No Significant difference has been shown between male and female experimental groups.
The findings of this research indicated that anticholinergic compounds, such as atropine can reduce chronic pain.